Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 11,700 | 6-8周 | ||
50 mg | ¥ 15,300 | 6-8周 | ||
100 mg | ¥ 19,500 | 6-8周 |
产品描述 | DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ. |
体外活性 | DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibit TNF-a-induced NF-kB activation. (-)-DHMEQ is more effective and less toxic than DHMEQ racemate. |
体内活性 | The anti-arthritis effect of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) on type II collagen-induced arthritis in DBA1/J mice was studied. Because of its pathological similarity to human rheumatoid arthritis, this animal model is widely used to evaluate anti-rheumatic drugs. Cause arthritis and score it. (-)-DHMEQ significantly inhibited type II collagen-induced arthritis in mice, while DHMEQ racemates tended to only slightly inhibit it. |
别名 | rel-DHMEQ |
分子量 | 261.23 |
分子式 | C13H11NO5 |
CAS No. | 287194-38-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (122.50 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.828 mL | 19.1402 mL | 38.2804 mL | 95.7011 mL |
5 mM | 0.7656 mL | 3.828 mL | 7.6561 mL | 19.1402 mL | |
10 mM | 0.3828 mL | 1.914 mL | 3.828 mL | 9.5701 mL | |
20 mM | 0.1914 mL | 0.957 mL | 1.914 mL | 4.7851 mL | |
50 mM | 0.0766 mL | 0.3828 mL | 0.7656 mL | 1.914 mL | |
100 mM | 0.0383 mL | 0.1914 mL | 0.3828 mL | 0.957 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DHMEQ racemate 287194-38-1 NF-Κb NF-κB rel-DHMEQ Inhibitor inhibitor inhibit